San Francisco will defend its unbeaten start when Washington visits Levi's Stadium in Santa Clara, California, on Monday, October 19, 2026.
The 5-0 49ers arrive after a 32-29 win over Seattle, while the 1-3-1 Commanders come in following a 27-27 tie with the New York Giants.
Kickoff is set for 5:15 p. m.
Pacific time, with the game airing nationally on ABC and ESPN.
Injury Concerns on Both Sides
San Francisco will be without defensive end Nick Bosa, who is dealing with knee and calf injuries, and receiver Deebo Samuel, sidelined by a hamstring issue.
Receiver Mike Evans is questionable for the 49ers because of rib and Achilles injuries.
Washington running back Jacory Croskey-Merritt is out with a groin injury, while receiver Stefon Diggs is listed as questionable.
The Commanders' challenge includes containing San Francisco's offense while managing their own personnel concerns.
Quarterback Jayden Daniels returned from a dislocated elbow against the Giants, recording 103 rushing yards and two rushing touchdowns, though the game ended in a tie after overtime.
San Francisco's defense forced four turnovers in its win over Seattle last week.
Predictive models cited by OregonLive project a 30-21 San Francisco win, giving the 49ers a 75.9% chance and Washington 24.1%, with projected combined scoring of 51 points.
The models project 249 passing yards and 20 rushing yards for 49ers quarterback Brock Purdy.
Daniels is projected for 210 passing yards and 42 rushing yards, reflecting the different expected roles of the two quarterbacks.
Washington's offensive outlook will depend partly on Daniels' mobility and the availability of its receiving options.
With Croskey-Merritt ruled out and Diggs uncertain, both teams carry injury-related questions into kickoff.
San Francisco is seeking to extend its unbeaten start, while Washington aims to improve its record after tying the Giants.
