Seiya Suzuki hit a game-ending, two-out single off Mason Miller in the ninth inning on Monday night to lift the Chicago Cubs to a 3-2 victory over the San Diego Padres at Wrigley Field.
The winning hit reached the left-field wall, extending Suzuki's hitting streak to four games and sealing Chicago's major league-leading 10th walk-off win of the season.
Dansby Swanson and Pete Crow-Armstrong initiated the decisive ninth-inning rally with consecutive singles off Jason Adam, who dropped to a 2-2 record.
Alex Bregman followed with a single to center field off Miller to load the bases.
Michael Busch then hit a flyball to left field, where Jase Bowen caught the ball and threw out Swanson at home plate as he attempted to score.
Suzuki followed by driving a pitch to the left-field wall, which Bowen narrowly missed catching during a leaping attempt.
Trent Thornton earned the victory to move to 3-2 after pitching the ninth inning for Chicago.
San Diego threat Fernando Tatis Jr. hit a one-out single in the frame but was thrown out by catcher Miguel Amaya trying to steal second base.
San Diego originally established a 2-0 advantage in the fourth inning when Miguel Andújar, who finished the game with three hits, scored on a double by Xander Bogaerts.
Chicago responded in the bottom half of the inning with an RBI single from Michael Conforto.
Suzuki initially tied the game at 2-2 with a sacrifice fly in the fifth inning.
He finished the night 2-for-4 with a double, a run scored, and two RBI, raising his batting average to .
317 over his last 10 contests.
Cubs left-hander Shota Imanaga allowed nine hits over 6 1/3 innings to record his first quality start since May 13.
San Diego starter Griffin Canning allowed five hits across 4 1/3 innings during his return to the conventional starting rotation.
The victory brings the Cubs to a 46-38 record after winning six of their last seven games, while the Padres fall to 43-39.
Prior to this three-game series in Chicago, the Padres had dropped two of three games to the Los Angeles Dodgers.
San Diego manager Craig Stammen previously praised left-hander JP Sears, who joined the rotation following an injury to Lucas Giolito and pitched 5.2 innings allowing two runs against his previous club last week.
"The way he threw the ball today is what he's capable of doing in the big leagues and what he has shown he did in the big leagues before we traded for him," said Stammen.
Stammen noted the importance of the depth piece after Sears earned a victory in his spot start last week.
"Exciting that he came up," said Stammen. "We needed him big.
He stepped up to the plate and just did an amazing job for us."
Sears is scheduled to start the second game of the series on Tuesday for San Diego against Chicago left-hander Matthew Boyd.