The Buffalo Bills will host the New England Patriots on Sunday, October 4, 2026, at the new Highmark Stadium in Orchard Park.
Buffalo enters the Week 4 AFC East matchup at 3-0, while New England sits at 1-2 under head coach Mike Vrabel.
The game pairs Buffalo's top-ranked scoring offense against New England's sixth-ranked scoring defense.
Running back James Cook leads the NFL with 346 rushing yards, and tight end Dalton Kincaid tops the team with 263 receiving yards.
Wide receiver DJ Moore has added a new dynamic to Buffalo's passing game after his offseason acquisition from Chicago.
On defense, Greg Rousseau has recorded six sacks, 14 quarterback pressures, and three forced fumbles through three games.
New England quarterback Drake Maye will look to rebound after a 35-6 loss to Jacksonville, as the offense struggles with turnovers and scoring efficiency.
Rivalry History and Injury Report
The rivalry has shifted since former Patriots quarterback Tom Brady departed.
Brady went 32-3 against Buffalo, but the Bills have gone 9-4 against New England in subsequent meetings.
The teams have split their season series over the past two years.
New England will be without cornerback Christian Gonzalez and defensive tackle Christian Barmore due to shoulder injuries.
Buffalo's secondary and backfield face potential depth adjustments, with defensive back Christian Benford listed as questionable.
Broadcast coverage begins at 1:00 PM ET on CBS, with streaming available via Fubo.
