San Francisco will welcome Washington to Levi's Stadium for Monday Night Football at 8:15 p. m.
ET, carrying a 5-0 record into the contest.
The Commanders arrive at 1-3-1 and have yet to win on the road this season.
The game sets San Francisco's productive offense against a Washington defense that has conceded 149 points across five games, an average of 29.8 per game.
San Francisco's Scoring Pace Meets a Leaky Washington Defense
The 49ers have put up 154 points, averaging 30.8 per game, while giving up 93 points, or 18.6 per contest.
Their unbeaten run opened with a 27-7 win over Los Angeles, followed by a 35-13 result against Miami and a 36-30 victory over Arizona.
San Francisco then beat Denver 24-14 before closing the stretch with a 32-29 road win at Seattle on Oct.
11.
Quarterback Brock Purdy has completed 98 of 142 passes for 1,196 yards with 13 touchdowns and two interceptions.
His passing yardage across the five games reads 205, 287, 297, 218 and 189.
Christian McCaffrey paces the ground game with 286 rushing yards and five touchdowns on 61 carries.
He has topped the team's rushing chart in four of five games, including 68 yards against Seattle, 52 against Denver and 75 against Arizona.
Mike Evans has 24 receptions for 326 yards and three touchdowns, though ESPN lists him as questionable.
George Kittle led the receiving corps against Miami with 80 yards and against Arizona with 82 yards.
San Francisco heads into the matchup with defensive personnel concerns.
Defensive end Nick Bosa is out with a calf injury, and safety Marques Sigle is sidelined by an ankle problem.
Defensive end Mykel Williams and cornerback Upton Stout are questionable, while wide receiver Christian Kirk sits on injured reserve.
Only two of San Francisco's five games have finished above 51 combined points, producing 66 and 61 points respectively.
The 49ers will look to protect their perfect record, while Washington chases a first road win of the campaign.
