Defensive and pitching depth carried the game as both teams combined for 27 strikeouts.
American League hurlers accounted for 15 of them amidst notable absences of stars Paul Skenes and Shohei Ohtani.
Injury struck early in the third inning when Tampa Bay's Junior Caminero left the game after being hit by a 97.6 mph sinker.
Subsequent X-rays returned negative.
The event celebrated the upcoming United States semiquincentennial with historical pregame ceremonies. Managers signed lineup cards with feathered quills surrounding 13 stars representing the original colonies.
With this victory, the American League extended its historical advantage to 49-45-2 overall. They have won 18 of the last 23 All-Star matchups.
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The next Major League Baseball All-Star Game is scheduled to take place at Wrigley Field in Chicago.