Luzardo remained on the mound into the sixth inning, where he gave up another solo home run to Derek Hill, trimming the Phillies' lead to 6-5.
Jonathan Bowlan relieved Luzardo in the seventh inning. He opened with an infield single that was complicated by a throwing error.
Three batters later, Colson Montgomery hit a game-tying single to make it 6-6.
The Phillies offense responded by loading the bases against Chicago reliever Bryan Hudson in the bottom of the seventh.
After an Alec Bohm lineout, Edmundo Sosa hit a sacrifice fly to drive in a run.
Former Phillie Seranthony Dominguez then threw a wild pitch with two strikes, giving Philadelphia an 8-6 cushion.
Brad Keller took over pitching duties for the Phillies in the eighth inning. He immediately encountered trouble with a leadoff single and a fielding error by Bryce Harper.
Keller escaped the jam when Rikuu Nishida lined out directly to him, enabling a double play to end the threat.
Jhoan Duran entered in the ninth inning to secure the final three outs.
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He used two strikeouts and defensive assistance from Bryson Stott to seal the win for Philadelphia.
