Saracens will face London rivals Harlequins on Saturday at StoneX Stadium in a pivotal penultimate regular-season match.
The team is targeting a top-four Premiership playoff spot during Director of Rugby Mark McCall's final home game in charge.
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A victory could lift Saracens above Exeter into fourth place in the Gallagher Premiership standings.
Saracens enter the contest on a four-match winning streak, including a 30-14 victory over Gloucester.
McCall's Legacy and Squad Changes
McCall has spent 17 years at the club, winning six English titles and three European championships in his 15 years as director of rugby.
Former technical director Brendan Venter is set to return next season to take over the first team.
Saracens have made three changes to the starting XV from the Gloucester win: Eroni Mawi, Hugh Tizard, and Tobias Elliott come in, while Rotimi Segun is out with a knee injury.
Harlequins, currently one point ahead of Gloucester for the final Champions Cup qualifying spot, have made one change: Sean Kerr replaces the injured Luke Northmore.
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McCall acknowledged the significance of the occasion but kept his focus on the match.
"As a group we have really enjoyed the last few weeks and are focused on making sure we finish the season strongly.
Harlequins will pose a lot of threats and we will be prepared for them," he said.
Reflecting on his long tenure, McCall added: "Saracens has been a huge part of my life for the last 17 years, so the final home game will obviously be significant.
But until the final whistle, my focus remains purely on the game and what is at stake for us."
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The regular season concludes next week with Saracens traveling to Sandy Park to face Exeter.
