The collision, involving a blue VW Golf and a white VW Polo, happened near a layby by Shooters Bottom car park at Beachy Head just before 9.30pm.
A passenger in one of the cars, a boy, aged 17, from Eastbourne, was sadly confirmed deceased at the scene.
Two other men in the car, a 19-year-old man, from Polegate, and a 21-year-old man, from Hellingly, were seriously injured.
The driver of the other car, a man, aged 21, from Eastbourne, was also seriously injured,” stated Sussex Police regarding the Beachy Head incident.
The Serious Collision Investigation Unit is actively seeking video footage from anyone who was present in the Beachy Head area during the fatal crash.
“This is a tragic incident and our thoughts are with those involved and their families.
We are aware there were a number of people in the area at the time of the collision and we would ask anyone who hasn’t spoken to us or has any video or dashcam footage to get in touch.
Please email collision. appeal@sussex.
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police. uk, quoting Operation Nashville,” said Detective Sergeant Ian Foxton.