The Princess explained her personal connection to the facility where she underwent months of preventative chemotherapy following major abdominal surgery in early 2024.
"I have taken on the National Three Peaks Challenge, not simply as a physical endeavour but as a chance to explore life beyond diagnosis and to give something back.
The Royal Marsden is a place that holds great meaning for me and whose care and expertise are life changing for so many people," she said.
The funds raised will support specialized research into establishing complementary therapies, including psychological support, nutrition, and physical activity, as standard nationwide medical treatments.
"Through this challenge, I want to raise awareness for the deeper impact of serious illness and the importance of holistic healthcare," Catherine said.
"Holistic therapies complement clinical pathways and support patients' ability to maintain their wellbeing, resilience and quality of life during an exceptionally difficult time."
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The royal shared insights into reshaping the availability of specialized recovery models across the United Kingdom.
"We have an opportunity to reshape what the future of holistic cancer care looks like, enabling more people, nationwide, to access the kind of personalised support that can help make a meaningful difference during and after medical treatment," she said.
A dedicated fundraising webpage was established by the charity to collect public donations inspired by the mountain trek.
"This challenge will support the Royal Marsden Cancer Charity, helping to transform access to, and understanding of, holistic care that will enhance recovery and healing for patients across the UK," Catherine said.