He finished the night 2-for-4 with a double, a run scored, and two RBI, raising his batting average to .
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317 over his last 10 contests.
Cubs left-hander Shota Imanaga allowed nine hits over 6 1/3 innings to record his first quality start since May 13.
San Diego starter Griffin Canning allowed five hits across 4 1/3 innings during his return to the conventional starting rotation.
The victory brings the Cubs to a 46-38 record after winning six of their last seven games, while the Padres fall to 43-39.
Prior to this three-game series in Chicago, the Padres had dropped two of three games to the Los Angeles Dodgers.
San Diego manager Craig Stammen previously praised left-hander JP Sears, who joined the rotation following an injury to Lucas Giolito and pitched 5.2 innings allowing two runs against his previous club last week.
"The way he threw the ball today is what he's capable of doing in the big leagues and what he has shown he did in the big leagues before we traded for him," said Stammen.
Stammen noted the importance of the depth piece after Sears earned a victory in his spot start last week.
"Exciting that he came up," said Stammen. "We needed him big.
He stepped up to the plate and just did an amazing job for us."
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Sears is scheduled to start the second game of the series on Tuesday for San Diego against Chicago left-hander Matthew Boyd.
