O'Neill indicated he is willing to adapt the team's traditional 4-3-3 system to accommodate both new signings.
"I would think that given the time that the two players should be able to play together without a problem," O'Neill said.
"I don't know what that means, changing systems, changing all that type of stuff. But, they're good players."
Duran has scored three goals in three preseason friendlies and has shown versatility by playing out wide.
"He [Duran] has played out wide as well, so that's encouraging. I'm not so sure that's eventually where I'll play him.
I see him being able to play as a striker or just off the striker," O'Neill said.
Reflecting on his previous tenure at Parkhead, O'Neill noted how squad structure dictates formation adjustments.
"We played a sort of a 3-5-2 for a lot of times," O'Neill said.
"But then we changed it when some teams cottoned on to it, in European matches as well. And then we ended up changing to 4-4-2.
We played that very often. But we had serious running power wide, which was great in those days."
O'Neill stressed that modern teams must be dynamic during matches.
"If it meant us having to adjust to get them [Duran and Hogh] to play together, that shouldn't be a problem.
Famous last words, but it shouldn't be," O'Neill said. "And this is the point.
We should be able to adapt. We've played this 4-3-3 system for quite some considerable time.
