I still think the same, I still dream, I still love my family. My body just doesn't cooperate," he said.
The former first-round draft pick played 10 NFL seasons for the Tennessee Titans, New York Jets, and Arizona Cardinals, rushing for 9,651 yards and 55 touchdowns.
He is one of nine players to surpass 2,000 rushing yards in a single season, achieving the feat in 2009.
His wife, Brittany Johnson, appeared alongside him during the interview to discuss the emotional impact on their family of four children.
"All I could think about was our kids and how young they are," she said.
She stated that while their previous life has changed, the family remains hopeful.
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Johnson joins a legacy of public figures raising awareness for the disease, which became globally recognized after New York Yankees player Lou Gehrig was diagnosed in the 1930s.
