In central Portugal's Vouzela area, more than 1,200 firefighters supported by nearly 400 vehicles and 15 aircraft were trying to extinguish a blaze that broke out on Thursday and had burned across an area of 13,000 hectares by Sunday.
Spain and Italy sent firefighters and aircraft to help, and emergency services stated on Monday that while dangerous spots remained, 80% of the blaze was under control.
Portugal's interior minister, Luís Neves, described conditions as a "powder keg".
Elsewhere, large fires also destroyed hundreds of hectares of forest, vineyards, and scrub on the Croatian island of Hvar and at Tale in Albania.
Meanwhile, in Greece, flames set off by a forest fire tore through two factories in the northern city of Thessaloniki.
Greek authorities issued evacuation alerts for three suburbs and urged residents in parts of the city to stay indoors and shut their windows and doors because of toxic smoke from one of the factories, a recycling plant.
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Another large wildfire broke out Sunday afternoon west of Athens, with 210 firefighters, supported by volunteers, specialized teams, and 29 aircraft deployed to tackle the blaze burning through pine forest in the Mandra area.