Potential Test debuts could be handed to Alice Capsey, Tilly Corteen-Coleman, or Mady Villiers.
"But some proper determination will go into every day we'll be playing here," she said.
The captain emphasized patience against India's disciplined batting lineup.
"India have had lots of success and some very experienced top batters that love batting for a long time," said Sciver-Brunt.
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She noted that India's batters are drilled to value their wickets highly.
"It's really drilled into the India batters that 'the value of your wicket is so important'. They will pose some great challenges for us to navigate," she said.
Sciver-Brunt remains confident her team can respond to tactical challenges.
"I'm sure we'll be thrown lots of different things while we are out there and hopefully we can throw some things back," she said.
The match also serves as an international farewell for veteran opener Tammy Beaumont, who announced her retirement effective at the end of the weekend.
"She's seen cricket through all of the changes that we've had," said Sciver-Brunt.
Beaumont ends her 17-year international career as England's leading centurion in one-day internationals.
"Seventeen years playing the game is a huge achievement in itself; she's obviously going to finish her career as the highest hundred scorer in the ODI format," said Sciver-Brunt.
The captain praised Beaumont's mental toughness and consistency.
"She's scored a lot of runs for our team and we've relied on those runs a lot of times.
She is someone who has got great determination and resolve in that, 'no one's going to get me out today, this is my day and I'm scoring runs'," said Sciver-Brunt.
The team aims to honor their departing teammate with a strong performance.
"That attitude will certainly be missed. Personally, as a friend, she will be missed in the team as well.
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I hope that we can send her off with a great week here at Lord's," said Sciver-Brunt.
