The Houston Astros defeated the Toronto Blue Jays 3-1 on Wednesday at Rogers Centre, capitalizing on a critical throwing error in the eighth inning to break a 1-1 tie.
Joey Loperfido scored the go-ahead run after hitting a triple.
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With Yainer Diaz at bat, Blue Jays reliever Jeff Hoffman threw wide to third base, allowing Loperfido to score easily.
Houston added an insurance run in the ninth inning when Jeremy Pena drove in Brice Matthews with an RBI single.
Astros starter Mike Burrows earned the win, striking out three over six innings while allowing two hits and one run.
Steven Okert, Bryan King, and Josh Hader closed out the game.
Isaac Paredes put Houston ahead early with an RBI double in the first inning.
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Toronto tied the game on a solo home run by Nathan Lukes in the bottom of the first.
Blue Jays starter Trey Yesavage allowed one run on two hits and five walks over 5 2/3 innings, striking out five.
He was replaced after throwing 105 pitches.
Toronto left runners in scoring position in five different innings but could not capitalize.
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The Blue Jays will open a three-game homestand against Texas on Thursday, with Kevin Gausman scheduled to start.