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Lindor finished the nightcap 0 for 4 in his return to the lineup after a two-month stint on the injured list.
The Mets also played without outfielder Juan Soto, who remained sidelined due to a back injury.
Despite the defensive miscues, the Mets hit four home runs during the doubleheader, with Vientos, Bichette, A. J.
Ewing, and Francisco Alvarez all going deep.
Chicago starting pitcher Shota Imanaga earned the victory in the nightcap, improving to 5-6 on the season after allowing four runs over 5 1/3 innings.
Gavin Hollowell provided relief, though he yielded a solo home run to Bichette in the sixth inning.
With the two losses, New York extended its losing streak to five games and dropped to a season-low 12 games under .
500.
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The four-game series concludes Thursday night at Citi Field, with Cubs left-hander Matthew Boyd expected to return from the injured list to face Mets right-hander Freddy Peralta.