Substitute Christian Pulisic provided an immediate spark upon his return from injury, nearly shifting the momentum with two close opportunities that narrowly missed the target.
During a chaotic sequence in the 63rd minute, a deflected effort from Pulisic struck the crossbar before a follow-up attempt from McKennie was quickly blocked by Turkish defenders.
The decisive blow arrived in the final seconds when Güler evaded two defenders near the corner flag to deliver a precise cross to the far post.
Kaan Ayhan stood unmarked and made no mistake with his close-range finish, securing a positive ending for Turkey and leaving the host nation with urgent defensive questions.
>>> Turkiye Stuns US with Late Winner in World Cup Group Stage
The US national team must now regroup as they prepare to face Bosnia and Herzegovina in the knockout round of the last-32.